The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate
janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling …

Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related
mortality, and is typically caused by interactions between CRC cells and the tumour …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …