Proteins and their assemblies are fundamental for living cells to function. Their complex
three-dimensional architecture and its stability are attributed to the combined effect of …

Low-barrier hydrogen bonds (LBHBs) are a special type of short hydrogen bond (HB) that is
characterized by the equal sharing of a hydrogen atom. The existence and catalytic role of …

Cytochrome c oxidase (C c O) is an essential enzyme in mitochondrial and bacterial
respiration. It catalyzes the four-electron reduction of molecular oxygen to water and …

Hydrogen bonds are fundamental to the structure and function of biological macromolecules
and have been explored in detail. The chains of hydrogen bonds (CHBs) and low-barrier …

The underlying molecular mechanisms of cooperativity and allosteric regulation are well
understood for many proteins, with haemoglobin and aspartate transcarbamoylase serving …

The method to calculate the energy of intramolecular hydrogen bond is proposed and tested
for a sample of malonaldehyde and its fluorine derivatives; the corresponding calculations …

This work considers how the properties of hydrogen bonded complexes, X–H⋯ Y, are
modified by the quantum motion of the shared proton. Using a simple two-diabatic state …

The three-dimensional architecture of biomolecules often creates specialized structural
elements, notably short hydrogen bonds that have donor–acceptor separations below 2.7 Å …

Carboxyl and carboxylate groups form important supramolecular motifs (synthons). Besides
carboxyl cyclic dimers, carboxyl and carboxylate groups can associate through a single …

Here, we report a novel mechanism to selectively degrade target proteins. 3-(3-
Phenoxybenzyl) amino-β-carboline (PAC), a tubulin inhibitor, promotes selective …