In the past two decades, record-breaking heatwaves have caused an increasing number of
heat-related deaths, including heatstroke, globally. Heatstroke is a heat illness characterized …

An elevated temperature has many aetiologies, both infective and non-infective, and while
the fever of sepsis probably confers benefit, there is increasing evidence that the central …

New Findings What is the topic of this review? The treatment of exertional heat stress, from
initial field care through the return‐to‐activity decision. What advances does it highlight …

Key points The human brain is particularly vulnerable to heat stress; this manifests as
impaired cognition, orthostatic tolerance, work capacity and eventually, brain death. The …

The blood-brain barrier (BBB) is a physiological regulator of transport of essential items from
blood to brain for the maintenance of homeostasis of the central nervous system (CNS) …

Heatstroke is an acute medical emergency that is always fatal if left untreated. The diagnosis
of heatstroke should be considered in any hyperthermic patient with altered mental status …

Background: The neuroinflammatory responses of microglial cells play an important role in
the process of brain dysfunction caused by heat stroke. MicroRNAs are reportedly involved …

Background Heat-related illness (HRI) is commonly considered an acute condition, and its
potential long-term consequences are not well understood. We conducted a population …

Maintenance of body temperature within physiological range is critical for the fetal and
neonatal development. Hyperthermia is one of the most frequently encountered pediatric …

Methods: This was a retrospective case series of patients admitted with features of HRI
during the summer of 2012 in our multidisciplinary ICU. Data on demographics, co-morbid …