Recent rodent models for Alzheimer's disease: clinical implications and basic research
Alzheimer's disease (AD) is the most common origin of dementia in the elderly. Although the
cause of AD remains unknown, several factors have been identified that appear to play a …
cause of AD remains unknown, several factors have been identified that appear to play a …
Accelerating Alzheimer's research through 'natural'animal models
Accelerating Alzheimer's research through ‘natural’ animal m... : Current Opinion in Psychiatry
Accelerating Alzheimer's research through ‘natural’ animal models : Current Opinion in …
Accelerating Alzheimer's research through ‘natural’ animal models : Current Opinion in …
Designing animal-friendly behavioral tests for neuroscience research: the importance of an ethological approach
Behavioral tests have three key elements:(1) a motivating factor (what motivates the animal
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …
in the test);(2) an observable behavior (which behaviors we may expect the animal exhibits …
Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus
Social isolation is considered a stressful situation that results in increased physiological
reactivity to novel stimuli, altered behaviour, and impaired brain function. Here, we …
reactivity to novel stimuli, altered behaviour, and impaired brain function. Here, we …
Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology
T van Groen, I Kadish, N Popović, M Popović… - Neurobiology of …, 2011 - Elsevier
Recently it has been shown that over 3-year-old wild-type South American rodents, Octodon
degus, the “common degu” or degu, of their own accord develop Alzheimer's disease …
degus, the “common degu” or degu, of their own accord develop Alzheimer's disease …
Effects of long-term individual housing of middle-aged female Octodon degus on spatial learning and memory in the Barnes maze task
N Popović, B Baño-Otalora, MÁ Rol… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction Prolonged social isolation is a form of passive chronic stress that has
consequences on human and animal behavior. The present study was undertaken to …
consequences on human and animal behavior. The present study was undertaken to …
Octodon degus: A Model for the Cognitive Impairment Associated with Alzheimer's Disease
E Tarragon, D Lopez, C Estrada… - CNS neuroscience & …, 2013 - Wiley Online Library
Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several
physiopathological conditions, analogous in many cases to those experienced by humans …
physiopathological conditions, analogous in many cases to those experienced by humans …
[HTML][HTML] “Live together, die alone”: The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social …
Loneliness affects group-living mammals triggering a cascade of stress-dependent
physiological disorders. Indeed, social isolation stress is a major risk factor for several …
physiological disorders. Indeed, social isolation stress is a major risk factor for several …
Octodon degus (Molina 1782): a model in comparative biology and biomedicine
One major goal of integrative and comparative biology is to understand and explain the
interaction between the performance and behavior of animals in their natural environment …
interaction between the performance and behavior of animals in their natural environment …
Long-term behavioral effects of social separation during early life in a social mammal, Octodon degus
R Ukyo, A Shinohara, C Koshimoto, GA Nagura-Kato… - Scientific Reports, 2023 - nature.com
Social separation is thought to induce a strong stress response in social juvenile mammals,
but little is known about how this response might vary throughout the development. The …
but little is known about how this response might vary throughout the development. The …