Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

Alzheimer's disease (AD) is a highly heritable complex disease with no current effective
prevention or treatment. The majority of drugs developed for AD focus on the amyloid …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …

Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …

Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four
genes have been established to either cause early-onset autosomal-dominant AD (APP …

Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …