Carbohydrates, one of the most abundant classes of biomolecules, are the structural
building blocks of genetic materials and vital source of energy. They are integral part of the …

DNA ligases are enzymes that seal breaks in the backbones of DNA, leading to them being
essential for the survival of all organisms. DNA ligases have been studied from many …

The reactions of sulfur ylides with carbonyl, olefin or imine compounds named as the Corey-
Chaykovsky, provide oxiranes, cyclopropane or aziridine, respectively. In this report, we try …

A highly chemo-and diastereoselective protocol toward amino-substituted donor–acceptor
cyclopropanes via the formal nucleophilic displacement in bromocyclopropanes is …

Tuberculosis faces major challenges for its cure due to (a) long treatment period,(b)
emergence of drug resistance bacteria, and (c) poor patient compliance. Disrupting the …

A highly diastereoselective protocol for the formal nucleophilic substitution of 2-
bromocyclopropylcarboxamides with azoles is described. A wide range of azoles, including …

In an attempt to identify novel inhibitors of NAD+-dependent DNA ligase (LigA) that are not
affected by a known resistance mutation in the adenosine binding pocket, a detailed …

Lymphatic filarial nematodes maintain a mutualistic relationship with the endosymbiont
Wolbachia. Depletion of Wolbachia produces profound defects in nematode development …

NAD+-dependent DNA ligase (LigA) is the essential replicative ligase in bacteria and differs
from ATP-dependent counterparts like the human DNA ligase I (HligI) in several aspects …

Identification of compounds distinguishing between NAD+ and ATP-dependent ligases is a
key factor to discover new antimicrobials. Based on virtual screening experiments a series of …