G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering
intracellular signaling through coupling with G proteins and arrestins. Recent breakthroughs …

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

G protein-coupled receptors (GPCRs) mediate diverse signaling in part through interaction
with arrestins, whose binding promotes receptor internalization and signaling through G …

The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

Light around twilight provides the primary entrainment signal for circadian rhythms. Here we
review the mechanisms and responses of the mouse and human circadian systems to light …

G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …

It is now established that most of the∼ 800 G-protein-coupled receptors (GPCRs) are
regulated by phosphorylation in a process that results in the recruitment of arrestins, leading …

G protein-coupled receptors (GPCRs) are targeted by about a third of clinically used drugs.
Many GPCRs couple to more than one type of heterotrimeric G proteins, become …

For decades, photoreceptors have been an outstanding model system for elucidating basic
principles in sensory transduction and biochemistry and for understanding many facets of …

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the
G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution …