Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association

MCP Nunes, A Beaton, H Acquatella, C Bern… - Circulation, 2018 - Am Heart Assoc
Background: Chagas disease, resulting from the protozoan Trypanosoma cruzi, is an
important cause of heart failure, stroke, arrhythmia, and sudden death. Traditionally …

Pathogenesis of chronic Chagas heart disease

JA Marin-Neto, E Cunha-Neto, BC Maciel, MV Simões - Circulation, 2007 - Am Heart Assoc
Background—Chagas disease remains a significant public health issue and a major cause
of morbidity and mortality in Latin America. Despite nearly 1 century of research, the …

Randomized trial of benznidazole for chronic Chagas' cardiomyopathy

CA Morillo, JA Marin-Neto, A Avezum… - … England Journal of …, 2015 - Mass Medical Soc
Background The role of trypanocidal therapy in patients with established Chagas'
cardiomyopathy is unproven. Methods We conducted a prospective, multicenter …

II Consenso Brasileiro em doença de Chagas, 2015

JCP Dias, AN Ramos Jr, ED Gontijo… - … e Serviços de …, 2016 - SciELO Public Health
RESUMO A doença de Chagas é uma condição crônica negligenciada com elevada carga
de morbimortalidade e impacto dos pontos de vista psicológico, social e econômico …

[HTML][HTML] 2 nd Brazilian Consensus on Chagas Disease, 2015

JCP Dias, AN Ramos Jr, ED Gontijo… - Revista da Sociedade …, 2016 - SciELO Brasil
Chagas disease is a neglected chronic condition with a high burden of morbidity and
mortality. It has considerable psychological, social, and economic impacts. The disease …

Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial

CA Morillo, H Waskin, S Sosa-Estani… - Journal of the American …, 2017 - jacc.org
Background: Benznidazole is recommended for treatment of Chagas infection. Effects of
combination therapy with benznidazole and posaconazole have not been tested in …

Diagnosis and management of Chagas disease and cardiomyopathy

AL Ribeiro, MP Nunes, MM Teixeira… - Nature Reviews …, 2012 - nature.com
Chagas cardiomyopathy is the most severe and life-threatening manifestation of human
Chagas disease—a'neglected'tropical disease caused by the protozoan parasite …

Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches

JA Urbina - Acta tropica, 2010 - Elsevier
A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

Myocarditis in humans and in experimental animal models

P Błyszczuk - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Myocarditis is defined as an inflammation of the cardiac muscle. In humans, various
infectious and non-infectious triggers induce myocarditis with a broad spectrum of …

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for …

A Rassi Jr, JA Marin, A Rassi - Memórias do Instituto Oswaldo Cruz, 2017 - SciELO Brasil
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic
Chagas disease, and is one of the leading causes of morbidity and death in Latin America …