Targeting cancer stem cell pathways for cancer therapy

L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

High ATP production fuels cancer drug resistance and metastasis: implications for mitochondrial ATP depletion therapy

M Fiorillo, B Ozsvari, F Sotgia, MP Lisanti - Frontiers in oncology, 2021 - frontiersin.org
Recently, we presented evidence that high mitochondrial ATP production is a new
therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the …

Cancer stem cell in prostate cancer progression, metastasis and therapy resistance

P Verma, N Shukla, S Kumari, MS Ansari… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Prostate cancer (PCa) is the most diagnosed malignancy in the men worldwide. Cancer
stem cells (CSCs) are the sub-population of cells present in the tumor which possess unique …

[HTML][HTML] Epigenetic regulation of cancer stem cells by the aryl hydrocarbon receptor pathway

S Akhtar, S Hourani, L Therachiyil, A Al-Dhfyan… - Seminars in cancer …, 2022 - Elsevier
Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells
generally referred as cancer stem cells (CSCs) that have been proposed as a strong …

Synthetic and medicinal perspective of fused-thiazoles as anticancer agents

S Pawar, K Kumar, MK Gupta… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer is second leading disease after cardiovascular disease. Presently,
Chemotherapy, Radiotherapy and use of chemicals are some treatments available these …

The metabolic inhibitor CPI-613 negates treatment enrichment of ovarian cancer stem cells

C Bellio, C DiGloria, DR Spriggs, R Foster… - Cancers, 2019 - mdpi.com
One of the most significant therapeutic challenges in the treatment of ovarian cancer is the
development of recurrent platinum-resistant disease. Cancer stem cells (CSCs) are …

Regulation of the migration of colorectal cancer stem cells via the TLR4/MyD88 signaling pathway by the novel surface marker CD14 following LPS stimulation

Y Li, J Shi, Z Liu, Y Lin, A Xie, W Sun… - Oncology …, 2023 - spandidos-publications.com
Cell surface markers are most widely used in the study of cancer stem cells (CSCs).
However, cell surface markers that are safely and stably expressed in CSCs have yet to be …

Hyperforin-mediated anticancer mechanisms in MDA-MB-231 cell line: insights into apoptotic mediator modulation and caspase activation

M Barathan, AK Zulpa, KM Vellasamy… - Journal of Taibah …, 2023 - Taylor & Francis
Breast cancer has been recorded as a frequent malignant cancer. The side effects of current
chemotherapy drugs are still a severe problem. Hence, naturally occurring phytochemicals …

Effects of combinatorial ubiquitinated protein-based nanovaccine and STING agonist in mice with drug-resistant and metastatic breast cancer

F Huang, N Pan, Y Wei, J Zhao, M Aldarouish… - Frontiers in …, 2021 - frontiersin.org
We previously reported that enriched ubiquitinated proteins (UPs) from tumor cells have the
potential to be used as immunotherapy vaccine against cancer. Here we enriched UPs from …

[HTML][HTML] Breast Cancer Stem Cells and Tumor Heterogeneity: Characteristics and Therapeutic Strategies

A Romaniuk-Drapała, E Totoń, M Taube, M Idzik… - Cancers, 2024 - mdpi.com
Simple Summary Breast cancer stem cells (BCSCs) are a small population of cells in breast
cancer tumors, playing a putative role in the cancer's progression. BCSC biomarkers are …