Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Regulation of Staphylococcus aureus Virulence

C Jenul, AR Horswill - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is a Gram-positive opportunistic pathogen that has evolved a
complex regulatory network to control virulence. One of the main functions of this …

Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: an overview

L Huang, C Wu, H Gao, C Xu, M Dai, L Huang, H Hao… - Antibiotics, 2022 - mdpi.com
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms

JM Kwiecinski, AR Horswill - Current opinion in microbiology, 2020 - Elsevier
Highlights•Phagocytes play both protective and detrimental roles in containing bloodstream
S. aureus.•S. aureus hijacks the host coagulation system and uses it to bind host …

The staphylococcal biofilm: adhesins, regulation, and host response

AE Paharik, AR Horswill - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
The Staphylococcus genus includes a diverse group of commensals that colonize mammals
on the skin or mucous membranes. Some of the best‐known members of this genus, such as …

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

N Branzk, A Lubojemska, SE Hardison, Q Wang… - Nature …, 2014 - nature.com
Neutrophils are critical for antifungal defense, but the mechanisms that clear hyphae and
other pathogens that are too large to be phagocytosed remain unknown. We found that …

Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases

G Pietrocola, G Nobile, S Rindi… - Frontiers in cellular and …, 2017 - frontiersin.org
Neutrophils, complement system and skin collectively represent the main elements of the
innate immune system, the first line of defense of the host against many common …

The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression

HA Crosby, PM Schlievert, JA Merriman, JM King… - PLoS …, 2016 - journals.plos.org
Staphylococcus aureus is a human commensal and opportunistic pathogen that causes
devastating infections in a wide range of locations within the body. One of the defining …

Staphylococcus aureus aggregation and coagulation mechanisms, and their function in host–pathogen interactions

HA Crosby, J Kwiecinski, AR Horswill - Advances in applied microbiology, 2016 - Elsevier
The human commensal bacterium Staphylococcus aureus can cause a wide range of
infections ranging from skin and soft tissue infections to invasive diseases like septicemia …

The Staphylococcus aureus ArlRS two‐component system regulates virulence factor expression through MgrA

HA Crosby, N Tiwari, JM Kwiecinski, Z Xu… - Molecular …, 2020 - Wiley Online Library
Summary The Gram‐positive bacterium, Staphylococcus aureus, is a versatile pathogen that
can sense and adapt to a wide variety of environments within the human host, in part …