CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two
counteracting enzyme families whose enzymatic activity controls the acetylation state of …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

Class IIa histone deacetylases (HDACs) regulate a variety of cellular processes, including
cardiac growth, bone development, and specification of skeletal muscle fiber type. Multiple …

The adult heart responds to stress signals by hypertrophic growth, which is often
accompanied by activation of a fetal cardiac gene program and eventual cardiac demise …

Abstract FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-
membrane protein, and mediates the formation of mitochondria-associated endoplasmic …

An inverse relationship exists between striated muscle fiber size and its oxidative capacity.
This relationship implies that muscle fibers, which are triggered to simultaneously increase …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …