Although human epidemiological and genetic studies are essential to elucidate the
aetiology of normal and aberrant ocular development, animal models have provided us with …

The lens capsule is a modified basement membrane that completely surrounds the ocular
lens. It is known that this extracellular matrix is important for both the structure and …

Adeno-associated viral gene therapy has shown great promise in treating retinal disorders,
with three promising clinical trials in progress. Numerous adeno-associated virus (AAV) …

Basement membranes (BMs) are thin sheets of extracellular matrix that outline epithelia,
muscle fibers, blood vessels and peripheral nerves. The current view of BM structure and …

Scientists and clinicians who study genetic alterations and disease have traditionally
described phenotypes in natural language. The considerable variation in these free-text …

Free swimming zebrafish larvae depend mainly on their sense of vision to evade predation
and to catch prey. Hence, there is strong selective pressure on the fast maturation of visual …

Over the last decade, the use of the zebrafish as a genetic model has moved beyond the
proof-of-concept for the analysis of vertebrate embryonic development to demonstrated …

Basement membranes (BMs) are considered to be uniform, approximately 100nm-thin
extracellular matrix sheets that serve as a substrate for epithelial cells, endothelial cells and …

Background The retinal vasculature is a capillary network of blood vessels that nourishes
the inner retina of most mammals. Developmental abnormalities or microvascular …

In this review we focus on the mechanisms, regulation, and cellular consequences of
nuclear migration in the developing retina. In the nervous system, nuclear migration is …