A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

The circulating proteome offers insights into the biological pathways that underlie disease.
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …

Background Smoking remains one of the leading preventable causes of death. Smoking
leaves a strong signature on the blood methylome as shown in multiple studies using the …

Protein biomarkers have been identified across many age-related morbidities. However,
characterising epigenetic influences could further inform disease predictions. Here, we …

Background: The epigenetic effects of individual environmental toxicants in tobacco remain
largely unexplored. Cadmium (Cd) has been associated with smoking-related health effects …

Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …

DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …