Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

Vascular endothelial cells, as well as smooth muscle cells, show heterogeneity with regard
to their receptor expression and reactivity. For the vascular wall to act as a functional unit …

The proximal tubule Na+/H+ exchanger 3 (NHE3), located in the apical dense microvilli
(brush border), plays a major role in the reabsorption of NaCl and water in the renal …

The control of renal vascular tone is important for the regulation of salt and water balance,
blood pressure and the protection against damaging elevated glomerular pressure. The K+ …

Regulation of renal vascular resistance plays a major role in controlling arterial blood
pressure. The endothelium participates in this regulation as endothelial derived …

Key points• Endothelial microprojections (MPs) are cellular extensions of endothelial cells
(ECs) that may be involved in regulation of smooth muscle cell (SMC) constriction in blood …

In response to hypoxia, the pulmonary artery normally constricts to maintain optimal
ventilation-perfusion matching in the lung, but chronic hypoxia leads to the development of …

We investigated the mechanisms behind the endothelial-derived hyperpolarization (EDH)-
induced renal vasodilation in vivo and in vitro in rats. We assessed the role of Ca 2+ …

We examined the endothelial transient receptor vanilloid 4 (TRPV4) channel's vasodilatory
signaling using mathematical modeling. The model analyzes experimental data by …

We used mathematical modeling to investigate nitric oxide (NO)-dependent vasodilatory
signaling in the arteriolar wall. Detailed continuum cellular models of calcium (Ca2+) …