This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Pluripotent stem cells derived from preimplantation embryos, primordial germ cells or
teratocarcinomas are currently unique in undergoing prolonged symmetrical self-renewal in …

Human disease results from loss of organ function. Whether the tissue failure results from
infarction, infection, trauma, or congenital malfunction, the ideal treatment would be regrowth …

Secreted proteins of the Wnt family play widespread roles in the regulation of embryonic
development, and aberrant activation of the canonical Wnt/β-catenin pathway is one of the …

Therapeutic application of human embryonic stem cells (hESCs) requires precise control
over their differentiation. However, spontaneous differentiation is prevalent, and growth …

MACF1 (microtubule actin cross-linking factor 1) is a multidomain protein that can associate
with microfilaments and microtubules. We found that MACF1 was highly expressed in …

There is near consensus that Wnt family molecules establish important gradients within
niches where hematopoietic stem cells (HSC) reside. We review recent papers suggesting …

Many different stem cell types have been shown to differentiate into cardiac muscle cells in
vitro but P19 embryonal carcinoma (EC) cells were one of the first examples described and …

The neuroepithelial layer of the developing eyecup contains multipotential precursor cells
that give rise to all of the neurons and the one glial cell type present in the adult retina …