Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

Small RNA molecules of about 20–30 nucleotides have emerged as powerful regulators of
gene expression and genome stability. Studies in fission yeast and multicellular organisms …

INTRODUCTION Changes in histone posttranslational modifications are associated with
epigenetic states that define distinct patterns of gene expression. Whereas sequence …

Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across
large domains and can be epigenetically inherited in a self-propagating manner …

The nuclear lamina is thought to be the primary mechanical defence of the nucleus.
However, the lamina is integrated within a network of lipids, proteins and chromatin; the …

Chromosomal regions can adopt stable and heritable alternative states resulting in bistable
gene expression without changes to the DNA sequence. Such epigenetic control is often …

RNAi-mediated heterochromatin assembly in fission yeast requires the RNA-induced
transcriptional silencing (RITS) complex and a putative RNA-directed RNA polymerase …

The organization of eukaryotic genomes into distinct structural and functional domains is
important for the regulation and transduction of genetic information. Here, we investigated …

Heterochromatin assembly, involving methylation of histone H3 lysine 9 (H3K9me),
regulates various chromosomal processes. In fission yeast, heterochromatin targeted to …