The use of RNA-based treatments in the field of cancer immunotherapy

M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

Succinic semialdehyde dehydrogenase deficiency: an update

M Didiasova, A Banning, H Brennenstuhl… - Cells, 2020 - mdpi.com
Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is a genetic disorder that
results from the aberrant metabolism of the neurotransmitter γ-amino butyric acid (GABA) …

Nature as blueprint: Global phenotype engineering of CHO production cells based on a multi-omics comparison with plasma cells

N Raab, N Zeh, R Kretz, L Weiß, A Stadermann… - Metabolic …, 2024 - Elsevier
Especially for the production of artificial, difficult to express molecules a further development
of the CHO production cell line is required to keep pace with the continuously increasing …

Synergistic promotion of transient transgene expression in CHO cells by PDI/XBP-1s co-transfection and mild hypothermia

X Zhang, Y Wang, D Yi, C Zhang, B Ning, Y Fu… - Bioprocess and …, 2024 - Springer
Transient gene expression system is an important tool for rapid production of recombinant
proteins in Chinese hamster ovary (CHO) cells. However, their low productivity is the main …

[HTML][HTML] Enhancing recombinant antibody yield in Chinese hamster ovary cells

CH Yang, HC Li, SY Lo - Tzu Chi Medical Journal, 2024 - journals.lww.com
A range of recombinant monoclonal antibodies (rMAbs) have found application in treating
diverse diseases, spanning various cancers and immune system disorders. Chinese …

Expression of glycosylated human prolactin in HEK293 cells and related N-glycan composition analysis

FD Silva, JE Oliveira, RP Freire, MF Suzuki, CR Soares… - AMB Express, 2019 - Springer
Prolactin (PRL) is a hormone produced by the pituitary gland with innumerable functions,
such as lactation, reproduction, osmotic and immune regulation. The present work describes …

Manipulation of Endoplasmic Reticulum Folding and Assembly Machinery for Improved Production of Complex Biotherapeutics

O Swindley - 2021 - etheses.whiterose.ac.uk
Chinese Hamster Ovary (CHO) cells ability to produce complex glycoproteins which do not
illicit an immune response in humans makes them ideal hosts cell factories for the …

[PDF][PDF] Біологічні аспекти отримання рекомбінантних протианемічних засобів

Д Приймак - 2021 - dspace.nuft.edu.ua
РЕФЕРАТ Кваліфікаційна робота присвячена розробленню технології виробництва
рекомбінантного еритропоетидину. Даний препарат використовується для лікування та …