Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Background Remodeling the tumor microenvironment (TME) to benefit cancer cells is crucial
for tumor progression. Although diffuse-type gastric cancer (DGC) preferentially interacts …

Liver disease is a severe public health concern worldwide. There is a close relationship
between the liver and cytokines, and liver inflammation from a variety of causes leads to the …

Immune checkpoint blockades are the most promising therapy in lung adenocarcinoma
(LUAD). However, the response rate remains limited, underscoring the urgent need for …

Purpose Uveal melanoma (UM) is the most common intraocular malignant tumor in adults.
Due to the lack of effective treatments for metastatic UM, the survival of UM has not changed …

IL-20 is a pleiotropic cytokine that belongs to the IL-10 family and has a variety of biological
functions in tissue homeostasis and regulation of host immune defenses. It signals through a …

Breast cancer is prone to relapse and metastasize to many vital organs, contributing to most
of the breast cancer-related death and accentuating the importance of systematic …

Abstract Interleukin-19 (IL-19) and Interleukin-20 (IL-20) are inflammatory cytokines
belonging to the IL-10 family with immunoregulatory properties. Emerging evidence …

Ovarian cancer is a prominent cancer worldwide with a relatively low survival rate for women
diagnosed. Many individuals are diagnosed in the late stage of the disease and are …

The dysregulated endocytic traffic of oncogenic receptors, such as the EGFR family
especially HER2, contributes to the uncontrolled activation of the downstream oncogenic …