Existing guidelines on the preparation (Planning Research and Experimental Procedures on
Animals: Recommendations for Excellence (PREPARE)) and reporting (Animal Research …

Preclinical studies have shown that mesenchymal stem cells have a positive effect in
perinatal brain injury models. The mechanisms that cause these neurotherapeutic effects …

Leukocyte adhesion deficiency type I (LAD-I) is a primary immunodeficiency caused by
mutations in the ITGB2 gene, which encodes for the CD18 subunit of β 2-integrins. Deficient …

Purpose To address confounding issues that have been noted in planning and conducting
studies to identify biomarkers of radiation injury, develop animal models to simulate these …

Adeno-associated virus (AAV)-based gene therapy is gaining popularity owing to its
excellent safety profile and effective therapeutic outcomes in a number of diseases …

Hematopoietic stem and progenitor cells depend on bone marrow (BM) stromal cells for
survival. Here, we present a protocol for performing three consecutive BM transplants in …

Solid tumors frequently coexist with a degree of local chronic inflammation. Recruited
myeloid cells can therefore be considered as interesting vehicles for tumor-targeted delivery …

Simple Summary In the years following World War II, scientists became very interested in the
effects of radiation, especially after the atomic bombs were dropped on Japan. They started …

Humanized mice, defined as mice with human immune systems, have become an emerging
model to study human hematopoiesis, infectious disease, and cancer. Here, we describe the …

BACKGROUND The NOD/SCID mouse model is a unique and sophisticated method to
study the survival of human platelets (PLTs) in vivo. Meanwhile, several research groups …