The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate
organisms. This ability to seal the paracellular route between cells allows internal tissues to …

Adult stem cells are maintained in niches, specialized microenvironments that regulate their
self-renewal and differentiation. In the adult Drosophila testis stem cell niche, somatic hub …

Aging causes stem cell dysfunction as a result of extrinsic and intrinsic changes. Decreased
function of the stem cell niche is an important contributor to this dysfunction. We use the …

Stem cells reside in and rely upon their niche to maintain stemness but must balance self-
renewal with the production of daughters that leave the niche to differentiate. We discovered …

Spermatogenesis is a critical part of reproduction in insects; however, its molecular
mechanism is still largely unknown. In this study, we identified a testis‐specific gene …

Stem cells are regulated by signals from their microenvironment, or niche. During
Drosophila hematopoiesis, a niche regulates prohemocytes to control hemocyte production …

Non-obstructive azoospermia (NOA) severely affects male infertility, however, the deep
mechanisms of this disease are rarely interpreted. In this study, we find that undifferentiated …

Spermatogenesis is a dynamic developmental process requiring precisely timed transitions
between discrete stages. Specifically, the germline undergoes three transitions: from mitotic …

Abstract In Drosophila melanogaster, transformer-2 (tra2) plays an essential role in the sex-
specific splicing of doublesex (dsx) and fruitless (fru), two key transcription factor genes that …

Stem cell niche is regulated by intrinsic and extrinsic factors. In the Drosophila testis, cyst
stem cells (CySCs) support the differentiation of germline stem cells (GSCs). However, the …