Quaternary Ammonium Salts of Cationic Lipopeptides with Lysine Residues—Synthesis, Antimicrobial, Hemolytic and Cytotoxic Activities

K Sikora, J Jędrzejczak, M Bauer, D Neubauer… - Probiotics and …, 2023 - Springer
Ultrashort cationic lipopeptides (USCLs) and quaternary ammonium salts constitute two
groups of cationic surfactants with high antimicrobial activity. This study aimed to investigate …

Changes in length and positive charge of palindromic sequence RWQWRWQWR enhance cytotoxic activity against breast cancer cell lines

AC Barragán-Cárdenas, DS Insuasty-Cepeda… - ACS …, 2023 - ACS Publications
Breast cancer is one of the main causes of premature death in women; current treatments
have low selectivity, generating strong physical and psychological sequelae. The …

Chimeric Peptides Derived from Bovine Lactoferricin and Buforin II: Antifungal Activity against Reference Strains and Clinical Isolates of Candida spp.

K Aguirre-Guataqui, M Márquez-Torres… - Antibiotics, 2022 - mdpi.com
Antimicrobial peptides (AMPs) are considered to be a valuable source for the identification
and/or design of promising candidates for the development of antifungal treatments, since …

[HTML][HTML] Antifungal Synergy: Mechanistic Insights into the R-1-R Peptide and Bidens pilosa Extract as Potent Therapeutics against Candida spp. through Proteomics

Y Vargas-Casanova, CP Bravo-Chaucanés… - International Journal of …, 2024 - mdpi.com
Previous reports have demonstrated that the peptide derived from LfcinB, R-1-R, exhibits
anti-Candida activity, which is enhanced when combined with an extract from the Bidens …

Evaluating the In Vitro Activity and Safety of Modified LfcinB Peptides as Potential Colon Anticancer Agents: Cell Line Studies and Insect-Based Toxicity Assessments

KJ Cárdenas-Martínez, AC Barragán-Cárdenas… - ACS …, 2023 - ACS Publications
Anticancer peptides are increasingly being considered as alternative treatments for cancer
due to their potency, selectivity, and low toxicity. Previously, the peptide LfcinB (21–25) Pal …

Lectin‐anticancer peptide fusion demonstrates a significant cancer‐cell‐selective cytotoxic effect and inspires the production of “clickable” anticancer peptide in …

R Pasupuleti, S Riedl, L Saltor Núñez… - Protein …, 2023 - Wiley Online Library
Targeted killing of tumor cells while protecting healthy cells is the pressing priority in cancer
treatment. Lectins that target a specific glycan marker abundant in cancer cells can be …

Optimizing the synthesis of dimeric peptides: influence of the reaction medium and effects that modulate kinetics and reaction yield

CFRC Guimarães, AS Félix, TAS Brandão… - Amino Acids, 2023 - Springer
Peptides are remarkably interesting alternatives to several applications. In particular,
antimicrobial sequences have raised major interest of the scientific community due to the …

[HTML][HTML] A New Methodology for Synthetic Peptides Purification and Counterion Exchange in One Step Using Solid-Phase Extraction Chromatography

AG López-Sánchez, KG Rodríguez-Mejía… - Processes, 2024 - mdpi.com
Synthetic peptides are commonly obtained by means of solid-phase peptide synthesis
(SPPS), in which separation of the peptide from the solid support requires treatment with …

In‐house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH‐related peptides

NM González‐López… - Biomedical …, 2023 - Wiley Online Library
Matrix effect and sample pretreatment significantly affect the percentage recovery of
peptides in biological matrices, affecting the method robustness and accuracy. To counteract …

Non-natural amino acids into LfcinB-derived peptides: effect in their (i) proteolytic degradation and (ii) cytotoxic activity against cancer cells

DS Insuasty-Cepeda… - Royal Society …, 2023 - royalsocietypublishing.org
The dimeric peptide 26 [F]:(RRWQWR F KKLG) 2-K-Ahx has exhibited a potent cytotoxic
effect against breast cancer cell lines, with position 26 (F) being the most relevant for anti …