Applications of next-generation sequencing technologies in functional genomics Page 1
Review Applications of next-generation sequencing technologies in functional genomics Olena …

Transcriptome analysis has been a key area of biological inquiry for decades. Over the
years, research in the field has progressed from candidate gene-based detection of RNAs …

This paper describes a new database that has been set up for partial,'single-pass' cDNA
sequences, also known as expressed sequence tags. Such sequences, and associated …

Ponders how many families of proteins exist. Estimation that the large majority of proteins
come from no more than one thousand families. How proteins are clustered into families; …

Four Caenorhabditis elegans genes encode muscle-type specific myosin heavy chain
isoforms: myo-1 and myo-2 are expressed in the pharyngeal muscles; unc-54 and myo-3 are …

Large-scale sequencing of cDNAs randomly picked from libraries has proven to be a very
powerful approach to discover (putatively) expressed sequences that, in turn, once mapped …

Mining the emerging abundance of microbial genome sequences for hypotheses is an
exciting prospect of “functional genomics”. At the forefront of this effort, we compared the …

As part of our effort to sequence the 100-megabase (Mb) genome of the nematode
Caenorhabditis elegans, we have completed the nucleotide sequence of a contiguous …

Caenorhabditis elegans is a rhabditid nematode. What relevance does this have for the
interpretation of the complete genome sequence, and how will it affect the exploitation of the …

Background High throughput sequencing-by-synthesis is an emerging technology that
allows the rapid production of millions of bases of data. Although the sequence reads are …