Merits and challenges of iPSC-derived organoids for clinical applications
Z Xu, J Yang, X Xin, C Liu, L Li, X Mei… - Frontiers in Cell and …, 2023 - frontiersin.org
Induced pluripotent stem cells (iPSCs) have entered an unprecedented state of
development since they were first generated. They have played a critical role in disease …
development since they were first generated. They have played a critical role in disease …
Biotechnological advances and applications of human pluripotent stem cell-derived heart models
P Muniyandi, C O'Hern, MA Popa… - … in Bioengineering and …, 2023 - frontiersin.org
In recent years, significant biotechnological advancements have been made in engineering
human cardiac tissues and organ-like models. This field of research is crucial for both basic …
human cardiac tissues and organ-like models. This field of research is crucial for both basic …
Dual-modality imaging system for monitoring human heart organoids beating in vitro
To reveal the three-dimensional microstructure and calcium dynamics of human heart
organoids (hHOs), we developed a dual-modality imaging system combining the …
organoids (hHOs), we developed a dual-modality imaging system combining the …
[HTML][HTML] ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes
Congenital heart defects constitute the most common birth defect in humans, affecting
approximately 1% of all live births. The incidence of congenital heart defects is exacerbated …
approximately 1% of all live births. The incidence of congenital heart defects is exacerbated …
A review of protocols for engineering human cardiac organoids
F Wu, Q He, F Li, X Yang - Heliyon, 2023 - cell.com
The use of human cardiac organoids (hCOs) as 3D in vitro models for cardiovascular
research has shown great promise. Human pluripotent stem cells (hPSCs) have proven to …
research has shown great promise. Human pluripotent stem cells (hPSCs) have proven to …
Promises and challenges of cardiac organoids
J Li, J Yang, D Zhao, W Lei, S Hu - Mammalian Genome, 2023 - Springer
Cardiovascular diseases are currently the main cause of death. The study of the
pathogenesis and treatment of these diseases is still a major challenge. Traditional 2D …
pathogenesis and treatment of these diseases is still a major challenge. Traditional 2D …
Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?
I Bissoli, S D'Adamo, C Pignatti, G Agnetti… - Frontiers in Cell and …, 2023 - frontiersin.org
A major limitation in studies aimed at investigating the molecular bases and pathogenetic
mechanisms in cardiac disease is the limited availability of cellular models capable of …
mechanisms in cardiac disease is the limited availability of cellular models capable of …