BACKGROUND DNA damage is a hazard that affects all cells of the body. DNA-damage
repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are …

Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …

Background Several studies around the world support the hypothesis that genetic
polymorphisms involved in folate metabolism could be related to the maternal risk for Down …

Background Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate
metabolic pathway which catalyzes the irreversible conversion of 5, 10 …

Down syndrome (DS) is the most common chromosomal abnormality. Many studies have
assessed the association between maternal gene polymorphisms involved in folate …

An etiologically complex disorder, Attention Deficit Hyperactivity Disorder (ADHD), is often
associated with various levels of cognitive deficit. Folate/vitamin B 9 is crucial for numerous …

ABSTRACT Background Vitamin B-12 (cobalamin) deficiency may produce severe
neurologic and hematologic manifestations. Approximately 20–25% of circulating cobalamin …

Abstract STUDY QUESTION Are DNMT3B promoter polymorphisms among maternal risk
factors for the birth of a child with Down syndrome (DS)? SUMMARY ANSWER Present …

Methylenetetrahydrofolate reductase (MTHFR) is the most important gene that participates in
folate metabolism. Presence of valine instead of alanine at position 677 and elevated levels …

Choline and betaine are essential nutrients involved in one-carbon metabolism and have
been hypothesised to affect breast cancer risk. Functional polymorphisms in genes …