Exosomes as a new frontier of cancer liquid biopsy

D Yu, Y Li, M Wang, J Gu, W Xu, H Cai, X Fang… - Molecular cancer, 2022 - Springer
Liquid biopsy, characterized by minimally invasive detection through biofluids such as
blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and …

Advances in multiplexed techniques for the detection and quantification of microRNAs

T Jet, G Gines, Y Rondelez, V Taly - Chemical Society Reviews, 2021 - pubs.rsc.org
MicroRNA detection is currently a crucial analytical chemistry challenge: almost 2000
papers were referenced in PubMed in 2018 and 2019 for the keywords “miRNA detection …

Point-of-care CRISPR/Cas nucleic acid detection: Recent advances, challenges and opportunities

JE van Dongen, JTW Berendsen… - Biosensors and …, 2020 - Elsevier
With the trend of moving molecular tests from clinical laboratories to on-site testing, there is a
need for nucleic acid based diagnostic tools combining the sensitivity, specificity and …

The CRISPR–Cas toolbox for analytical and diagnostic assay development

Y Tang, L Gao, W Feng, C Guo, Q Yang, F Li… - Chemical Society …, 2021 - pubs.rsc.org
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-
associated (Cas) systems have revolutionized biological and biomedical sciences in many …

Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

CRISPR‐Cas biochemistry and CRISPR‐based molecular diagnostics

Z Weng, Z You, J Yang, N Mohammad… - Angewandte Chemie …, 2023 - Wiley Online Library
Polymerase chain reaction (PCR)‐based nucleic acid testing has played a critical role in
disease diagnostics, pathogen surveillance, and many more. However, this method requires …

Construction of an integrated device of a self-powered biosensor and matching capacitor based on graphdiyne and multiple signal amplification: ultrasensitive method …

YY Hou, J Xu, FT Wang, Z Dong, X Tan… - Analytical …, 2021 - ACS Publications
The detection of microRNA (miRNA) in human serum has great significance for cancer
prevention. Herein, a novel self-powered biosensing platform is developed, which effectively …

CRISPR/cas systems redefine nucleic acid detection: principles and methods

M Wang, R Zhang, J Li - Biosensors and Bioelectronics, 2020 - Elsevier
Methods that enable rapid, sensitive and specific analyses of nucleic acid sequences have
positive effects on precise disease diagnostics and effective clinical treatments by providing …

Electrochemical biosensor for ultrasensitive exosomal miRNA analysis by cascade primer exchange reaction and MOF@ Pt@ MOF nanozyme

X Li, X Li, D Li, M Zhao, H Wu, B Shen, P Liu… - Biosensors and …, 2020 - Elsevier
Exosomal miRNAs have been discovered as important and reliable biomarkers for early
diagnosis of tumors. However, it is still challenging to achieve accurate determination of …

CRISPR/Cas13a powered portable electrochemiluminescence chip for ultrasensitive and specific MiRNA detection

T Zhou, R Huang, M Huang, J Shen, Y Shan… - Advanced …, 2020 - Wiley Online Library
MicroRNAs (miRNAs) have been widely investigated as potential biomarkers for early
clinical diagnosis of cancer. Developing an miRNA detection platform with high specificity …