Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Progress in development of biophysical analytic approaches has recently crossed paths with
macromolecule condensates in cells. These cell condensates, typically termed liquid-like …

INTRODUCTION In human cells, 2 m of DNA are compacted in the nucleus through
assembly with histones and other proteins into chromatin structures, megabase three …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

We describe a Hi-C-based method, Micro-C, in which micrococcal nuclease is used instead
of restriction enzymes to fragment chromatin, enabling nucleosome resolution chromosome …

Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …

Revealing the energy landscape for nucleosome association may contribute to the
understanding of higher-order chromatin structures and their impact on genome regulation …

Linker histones bind to the nucleosome and regulate the structure of chromatin and gene
expression. Despite more than three decades of effort, the structural basis of nucleosome …

Recent methodological advancements in microscopy and DNA sequencing-based methods
provide unprecedented new insights into the spatio-temporal relationships between …

The existence of a 30‐nm fiber as a basic folding unit for DNA packaging has remained a
topic of active discussion. Here, we characterize the supramolecular structures formed by …