Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the~ 10
13 blood and immune cells distributed throughout the human body. We argue that a …

Hematopoiesis, or the process of blood cell production, is a paradigm of multi‐lineage
cellular differentiation that has been extensively studied, yet in many aspects remains …

The paradigmatic hematopoietic tree model is increasingly recognized to be limited, as it is
based on heterogeneous populations largely defined by non-homeostatic assays testing cell …

Stem cell division is linked to tumorigenesis by yet-elusive mechanisms. The hematopoietic
system reacts to stress by triggering hematopoietic stem and progenitor cell (HSPC) …

The discovery of a fetal origin for tissue-resident macrophages (trMacs) has inspired an
intense search for the mechanisms underlying their development. Here, we performed in …

Age-related morbidity is associated with a decline in hematopoietic stem cell (HSC) function,
but the mechanisms of HSC aging remain unclear. We performed heterochronic HSC …

Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types
of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or …

Platelet dysregulation is drastically increased with advanced age and contributes to making
cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a …

Ageing is associated with changes in the cellular composition of the immune system. During
ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are …

Highlights•Cellular lineage commitment within hematopoiesis is reviewed.•Insights from
novel lineage tracing and single-cell transcriptomics studies are discussed.•How single cell …