In vitro and in vivo toxicity assessment of nanoparticles

V Kumar, N Sharma, SS Maitra - International Nano Letters, 2017 - Springer
Nanotechnology has revolutionized gene therapy, diagnostics and environmental
remediation. Their bulk production, uses and disposal have posed threat to the environment …

Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond

L Luzhna, P Kathiria, O Kovalchuk - Frontiers in genetics, 2013 - frontiersin.org
Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …

Toxicity assessment of nanomaterials: methods and challenges

A Dhawan, V Sharma - Analytical and bioanalytical chemistry, 2010 - Springer
The increasing use of nanomaterials in consumer and industrial products has aroused
global concern regarding their fate in biological systems, resulting in a demand for parallel …

[HTML][HTML] Graphene as cancer theranostic tool: progress and future challenges

M Orecchioni, R Cabizza, A Bianco, LG Delogu - Theranostics, 2015 - ncbi.nlm.nih.gov
Nowadays cancer remains one of the main causes of death in the world. Current diagnostic
techniques need to be improved to provide earlier diagnosis and treatment. Traditional …

The new toxicology of sophisticated materials: nanotoxicology and beyond

AD Maynard, DB Warheit, MA Philbert - Toxicological sciences, 2011 - academic.oup.com
It has long been recognized that the physical form of materials can mediate their toxicity—
the health impacts of asbestiform materials, industrial aerosols, and ambient particulate …

Safe clinical use of carbon nanotubes as innovative biomaterials

N Saito, H Haniu, Y Usui, K Aoki, K Hara… - Chemical …, 2014 - ACS Publications
Carbon nanotubes (CNTs) are structurally described as sheets of six-membered carbon
atom rings (ie, graphene) rolled up into cylinders. CNTs with only one layer are known as …

The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo

X Li, H Liu, X Niu, B Yu, Y Fan, Q Feng, F Cui, F Watari - Biomaterials, 2012 - Elsevier
Carbon nanotubes (CNTs), one of the most concerned nanomaterials, with unique electrical,
mechanical and surface properties, have been shown suitable for biomedical application. In …

[HTML][HTML] In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

SH Doak, B Manshian, GJS Jenkins, N Singh - Mutation Research/Genetic …, 2012 - Elsevier
There is a pressing requirement to define a hazard identification and risk management
strategy for nanomaterials due to the rapid growth in the nanotechnology industry and their …

Review of carbon nanotubes toxicity and exposure—Appraisal of human health risk assessment based on open literature

K Aschberger, HJ Johnston, V Stone… - Critical reviews in …, 2010 - Taylor & Francis
Carbon nanotubes (CNTs) possess many unique electronic and mechanical properties and
are thus interesting for numerous novel industrial and biomedical applications. As the level …

High throughput toxicity screening and intracellular detection of nanomaterials

AR Collins, B Annangi, L Rubio… - Wiley …, 2017 - Wiley Online Library
With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and
reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical …