The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

The PEA3 subfamily is a subgroup of the E26 transformation-specific (ETS) family. Its
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …

The mammalian kidney develops through reciprocal interactions between the ureteric bud
and the metanephric mesenchyme to give rise to the entire collecting system and the …

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects
derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the …

Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of
6% despite promising responses to upfront combination chemotherapy. The key drivers of …

The mammalian lung forms its elaborate tree-like structure following a largely stereotypical
branching sequence. While a number of genes have been identified to play essential roles …

The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the
renal collecting system. Although development of a normal kidney depends on proper …

Signaling by GDNF through the Ret receptor tyrosine kinase is required for the normal
growth and morphogenesis of the ureteric bud (UB) during kidney development. Recent …

The pluripotency and self-renewal capacity of embryonic stem (ES) cells is regulated by
several transcription factors. Here, we show that the ETS-related transcription factors Etv4 …

The mammalian kidney, which at maturity contains thousands of nephrons joined to a highly
branched collecting duct (CD) system, is an important model system for studying the …