Organisms respond to mitochondrial stress through the upregulation of an array of protective
genes, often perpetuating an early response to metabolic dysfunction across a lifetime. We …

Candida albicans is a commensal fungus of the human gastrointestinal tract and a prevalent
opportunistic pathogen. To examine diversity within this species, extensive genomic and …

Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play an
integral role in protecting linear DNA from degradation. Dysregulation of telomeres can …

Genetic variability, epigenetic variability, and gene expression variability (noise) are
generally considered independently in their relationship with phenotypic variation. However …

Genes are not randomly distributed in the genome. In humans, 10% of protein‐coding genes
are transcribed from bidirectional promoters and many more are organised in larger clusters …

DNA is organized into complex three-dimensional chromatin structures, but how this spatial
organization regulates gene expression remains a central question. These DNA/chromatin …

Expression levels of many microRNAs (miRNAs) change during aging, notably declining
globally in a number of organisms and tissues across taxa. However, little is known about …

The human commensal and opportunistic fungal pathogen Candida albicans displays
extensive genetic and phenotypic variation across clinical isolates. Here, we performed RNA …

Candida albicans is a major human fungal pathogen that encounters varied host
environments during infection. In response to environmental cues, C. albicans switches …

Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly
understood whether and how heterochromatin differs between different organisms and …