Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci
have been the prototypical candidates for genetic susceptibility to infectious disease …

The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the
urgent need to refocus on the question of which T-cell responses are required to control HIV …

Deep sequencing technologies have the potential to transform the study of highly variable
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …

Introduction Heterosexual HIV-1 transmission is an inefficient process with rates reported at<
1% per unprotected sexual exposure. When transmission occurs, systemic infection is …

The ongoing COVID-19 pandemic has caught the attention of the global community and
rekindled the debate about our ability to prevent and manage outbreaks, epidemics, and …

HIV is a disease in which the original clinical observations of severe opportunistic infections
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …

HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and
killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide …

Abstract “HIV controllers”(HICs) are rare individuals in whom HIV-1 plasma viral load
remains undetectable without antiretroviral treatment. This spontaneous viral control in HICs …

The pattern of viral diversification in newly infected individuals provides information about
the host environment and immune responses typically experienced by the newly transmitted …

HLA-B* 57 is the class I allele most consistently associated with control of human
immunodeficiency virus (HIV) replication, which may be linked to the specific HIV peptides …