The sarcomere is the fundamental structural and functional unit of striated muscle and is
directly responsible for most of its mechanical properties. The sarcomere generates active or …

The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate
contraction force in the heart. Based on recent advancements and the historical literature …

The heart pumps blood against the mechanical afterload from arterial resistance, and
increased afterload may alter cardiac electrophysiology and contribute to life-threatening …

Aims Sex differences in heart failure with preserved ejection fraction (HFpEF) are important,
but key mechanisms involved are incompletely understood. While animal models can inform …

Cardiac mechanical afterload induces an intrinsic autoregulatory increase in myocyte Ca2+
dynamics and contractility to enhance contraction (known as the Anrep effect or slow force …

Background The pathobiology of heart failure with preserved ejection fraction (HFpEF) is still
poorly understood, and effective therapies remain limited. Diabetes and mineralocorticoid …

Cardiometabolic syndromes including diabetes and obesity are associated with occurrence
of heart failure with diastolic dysfunction. There are no specific treatments for diastolic …

We develop a viscoelastic generalization of the elastic Eshelby inclusion solution, where the
inclusion and surrounding matrix are two different viscoelastic solids and the inclusion's …

Mechanical load is a potent regulator of cardiac structure and function. Although high
workload during heart failure is associated with disruption of cardiomyocyte t‐tubules and …

The heart has two intrinsic mechanisms to enhance contractile strength that compensate for
increased mechanical load to help maintain cardiac output. When vascular resistance …