Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

The human mitochondrial genome involves over 1,000 genes, dispersed across the
maternally inherited mitochondrial DNA (mtDNA) and the biparentally inherited nuclear DNA …

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic
diseases, cancer, and aging. All these clinical manifestations arise from the central role of …

The epigenome has been hypothesized to provide the interface between the environment
and the nuclear DNA (nDNA) genes. Key factors in the environment are the availability of …

Only a limited number of complete mitochondrial genome sequences belonging to Native
American haplogroups were available until recently, which left America as the continent with …

It is now clear that mitochondrial defects are associated with a plethora of clinical
phenotypes in man and mouse. This is the result of the mitochondria's central role in energy …

Huge investments in biomedical research in the recent past have resulted in some striking
accomplishments, including the sequencing of the human chromosomal DNA (Lander et al …

Objective Some studies indicate that the mitochondrion is implicated in osteoarthritis (OA).
To test the hypothesis that mitochondrial DNA (mtDNA) haplogroups contribute to the …

According to current estimates, infertility affects one in four couples trying to conceive.
Primary or secondary infertility can be due either to both partners or only to the man or the …