SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Type 2 diabetes with obesity-related insulin resistance as the main manifestation is
associated with an increased risk of cognitive impairment. Adipose tissue plays an important …

Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

Neuropeptides are found in many mammalian CNS neurons where they play key roles in
modulating neuronal activity. In contrast to amino acid transmitter release at the synapse …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of
energy homeostasis and body weight. Leptin deficiency or genetic defects in the …

Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …

Depression is a multicausal disorder and has been associated with the risk to develop
cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has …

Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial
amyotrophic lateral sclerosis (FALS); however, it is not clear how FUS mutations cause …