Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

Alzheimer′ s disease (AD) is the most common type of dementia. In connection with the
global trend of prolonging human life and the increasing number of elderly in the population …

Alzheimer's disease (AD) is characterized by cognitive impairment, progressive
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …

Studies of post-mortem tissue have shown that the location of fibrillar tau deposits, called
neurofibrillary tangles (NFT), matches closely with regions of massive neuronal death …

Neurofibrillary tangles (NFTs) are composed of abnormal aggregates of the cytoskeletal
protein tau. Together with amyloid β (Aβ) plaques and neuronal and synaptic loss, NFTs …

Despite our present knowledge of some of the cellular pathways that modulate central
nervous system injury, complete therapeutic prevention or reversal of acute or chronic …

The caspases are unique proteases that mediate the major morphological changes of
apoptosis and various other cellular remodeling processes. As we catalog and study the …

Death-mediating proteases such as caspases and caspase-3 in particular, have been
implicated in neurodegenerative processes, aging and Alzheimer's disease. However …

Alzheimer's disease (AD) is the most common cause of dementia that arises on a
neuropathological background of amyloid plaques containing β-amyloid (Aβ) derived from …

Neurogenesis occurs in the adult mammalian brain and may play roles in learning and
memory processes and recovery from injury, suggesting that abnormalities in neural …