Spatiotemporal evolution of AML immune microenvironment remodeling and RNF149-driven drug resistance through single-cell multidimensional analysis

X Wu, Z Wu, W Deng, R Xu, C Ban, X Sun… - Journal of Translational …, 2023 - Springer
Background The composition of the bone marrow immune microenvironment in patients with
acute myeloid leukaemia (AML) was analysed by single-cell sequencing and the …

Neo212, a perillyl alcohol-temozolomide conjugate, triggers macrophage differentiation of acute myeloid leukemia cells and blocks their tumorigenicity

TC Chen, RO Minea, S Swenson, Z Yang, TZ Thein… - Cancers, 2022 - mdpi.com
Simple Summary Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow,
where cancer cells are unable to complete the maturation process towards white blood cells …

Analysis and clinical characteristics of acute myeloid leukemia developing with prior or concurrent tumors in non cyto-or radiotherapy exposure patients in a single …

Y Lian, J Ti, L Ma, J Wei, Z Gao - Hematology, 2023 - Taylor & Francis
Acute myeloid leukemia (AML) that develops along with prior or concurrent tumors without
previous cyto-or radiotherapy (pc-AML) is an essential subset of AML but is often ignored …

[HTML][HTML] Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review

L Liu, M Zhong, X Zhou, F Kang, Y Long… - OncoTargets and …, 2024 - ncbi.nlm.nih.gov
Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive malignancy.
Most patients are diagnosed at a late stage with poor prognosis. The treatment usually …

Potentially curative therapeutic activity of neo212, a perillyl alcohol-temozolomide conjugate, in preclinical cytarabine-resistant models of acute myeloid leukemia

AH Schönthal, S Swenson, RO Minea, HN Kim, H Cho… - Cancers, 2021 - mdpi.com
Simple Summary Many patients are still dying from acute myeloid leukemia (AML). Initial
treatment of this blood-borne cancer consists of chemotherapy, usually with the agent …

Incidental identification of inv (16)(p13. 1q22)/CBFB–MYH11 variant transcript in a patient with therapy-related acute myeloid leukemia by routine leukemia …

AE Quesada, R Luthra, E Jabbour… - Molecular …, 2021 - molecularcasestudies.cshlp.org
A 52-yr-old woman presented with therapy-related acute myeloid leukemia. A bone marrow
biopsy showed 21% blasts with a myeloid phenotype and no other notable features such as …

Survival of older adults with newly diagnosed acute myeloid leukemia: effect of using multiagent versus single-agent chemotherapy

VR Bhatt, V Shostrom, SA Holstein… - … Myeloma and Leukemia, 2020 - Elsevier
Background Controversy exists regarding the optimal chemotherapy regimen for older
adults with acute myeloid leukemia (AML). Patients and Methods We analyzed data from the …

A real-world, retrospective, observational study examining treatment patterns and clinical outcomes in patients with FLT3m+ AML in Japan

T Kiguchi, M Sakurai, Y Tanaka… - Current Medical …, 2023 - Taylor & Francis
Objective Acute myeloid leukemia (AML) is the most common form of leukemia among
adults in Japan. This study aimed to understand the treatment patterns, health care resource …

Survival Outcomes and Prognostic Factors in Therapy-Related Acute Myeloid Leukemia: A SEER Database Study, 2000-2020

U Joshi, U Bhetuwal, SK Yadav, P Budhathoki… - … Myeloma and Leukemia, 2024 - Elsevier
Introduction With advances in therapeutics and longer survival across different cancer
spectrums, the incidence of therapy-related acute myeloid leukemia (tAML) has continued to …

[HTML][HTML] Therapy-related acute myeloid leukemia following TCHP chemotherapy in two HER2+ breast cancer patients

N Gill, A Chandran, B Adley, J Bitran - Cureus, 2020 - ncbi.nlm.nih.gov
Increased risk for the development of therapy-induced myeloid leukemia following the
treatment of breast cancer has typically been associated with the use of regimens containing …