DNA damage response (DDR) pathway prevents high level endogenous and environmental
DNA damage being replicated and passed on to the next generation of cells via an …

Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …

Cancer is a black spot on the face of humanity in this era of science and technology.
Presently, several classes of anticancer drugs are available in the market, but issues such …

The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase
(ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of …

Abstract Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only
known target of the alkaloid camptothecin, from which the potent anticancer agents …

Protein phosphorylation regulates most aspects of cell life, whereas abnormal
phosphorylation is a cause or consequence of disease. A growing interest in developing …

The specificities of 28 commercially available compounds reported to be relatively selective
inhibitors of particular serine/threonine-specific protein kinases have been examined …

Multiple pathways are involved in maintaining the genetic integrity of a cell after its exposure
to ionizing radiation. Although repair mechanisms such as homologous recombination and …

Abstract p53 protects mammals from neoplasia by inducing apoptosis, DNA repair and cell
cycle arrest in response to a variety of stresses. p53-dependent arrest of cells in the G1 …

Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging
agents. These agents can either be exogenous or formed within cells. Environmental DNA …