Atherosclerosis is a complex and heritable disease involving multiple cell types and the
interactions of many different molecular pathways. The genetic and molecular mechanisms …

Plasma high-density lipoprotein cholesterol (HDL-C) concentrations are genetically
determined to a great extent, and quantitative trait locus (QTL) analysis has been used to …

The microbial communities that inhabit the distal gut of humans and other mammals exhibit
large inter-individual variation. While host genetics is a known factor that influences gut …

We report a combined genetic and genomic analysis of atherosclerosis in a cross between
the strains C3H/HeJ and C57BL/6J on a hyperlipidemic apolipoprotein E–null background …

Susceptibility to atherosclerosis is determined by both environmental and genetic factors. Its
genetic determinants have been studied by use of quantitative-trait–locus (QTL) analysis. So …

Identifying quantitative trait locus (QTL) genes is a challenging task. Herein, we report using
a two-step process to identify Apoa2 as the gene underlying Hdlq5, a QTL for plasma high …

Abstract Background The prevalence of Type 2 Diabetes (T2D) mellitus in the past decades,
has reached epidemic proportions. Several lines of evidence support the role of genetic …

There are well-known genetic background effects on atherosclerosis susceptibility in mice.
To study the basis of these effects, we have generated the apolipoprotein E-null mutation in …

Epidermal growth factor receptor (EGFR) signaling contributes to aortic valve development
in mice. Because developmental phenotypes in Egfr-null mice are dependent on genetic …

Peroxiredoxin 6 (Prdx6; also called antioxidant protein 2, or Aop2) is a candidate gene for
Ath1, a locus responsible for the respective susceptibility and resistance of mouse strains …