Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …

To understand the function of cortical circuits, it is necessary to catalog their cellular
diversity. Past attempts to do so using anatomical, physiological or molecular features of …

A key obstacle to understanding neural circuits in the cerebral cortex is that of unraveling the
diversity of GABAergic interneurons. This diversity poses general questions for neural circuit …

Systematic genetic access to GABAergic cell types will facilitate studying the function and
development of inhibitory circuitry. However, single gene-driven recombinase lines mark …

Traditionally, neuroscientists have defined the identity of neurons by the cells' location,
morphology, connectivity and excitability. However, the direct relationship between these …

An understanding of the diversity of cortical GABAergic interneurons is critical to understand
the function of the cerebral cortex. Recent data suggest that neurons expressing three …

INTRODUCTION The intricate microcircuitry of the cerebral cortex is thought to be a critical
substrate from which arise the impressive capabilities of the mammalian brain. Until now …

Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions
that are supported by the neocortex. The neocortex, which forms almost 80% of the human …