Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …

Mechanisms that integrate the metabolic state of a cell with regulatory pathways are
necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites …

L-lactate was long considered a glycolytic by-product but is now being recognized as a
signaling molecule involved in cell survival. In this manuscript, we report the role of L-lactate …

The pathways that impact longevity in the wake of dietary restriction (DR) remain still ill-
defined. Most studies have focused on nutrient limitation and perturbations of energy …

High salinity, an adverse environmental factor affecting about 20% of irrigated arable land
worldwide, inhibits plant growth and development by causing oxidative stress, damaging …

The molecular causes of type 2 diabetes (T2D) are not well understood. Both type 1
diabetes (T1D) and T2D are characterized by impaired insulin signaling and hyperglycemia …

Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …

Background Environment and diet in early life can affect development and health throughout
the life course. Metabolic phenotyping of urine and serum represents a complementary …