Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms
that counteract the effect of chemotherapeutic compounds, leading to relapse and the …

Unlike other normal cells, a subpopulation of cells often termed as “stem cells” are long-lived
and generate cellular progeny throughout life. Cancer stem cells (CSCs) are rare immortal …

Hepatocellular carcinoma (HCC) contains a subset of cancer stem cells (CSC) that cause
tumor recurrence, metastasis, and chemical resistance. Histone deacetylase 11 (HDAC11) …

The majority of women diagnosed with epithelial ovarian cancer eventually develop
recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian …

Over the last two decades, several epi‐drugs, immune checkpoint inhibitors (ICIs) and
adoptive cell therapies have received clinical approval for use in certain types of cancer …

Arsenic, cadmium, nickel and hexavalent chromium are among the most common
environmental pollutants and potent carcinogens. Chronic exposure to these metals causes …

Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms
normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Cancer
stem cells (CSCs) that exist within the bulk tumor survive first-line chemotherapy and …

We previously discovered a novel sirtuin (SIRT) inhibitor, MHY2256, that exerts anticancer
activity through p53 acetylation in MCF-7 human breast cancer cells. We investigated the …

At present, after extensive studies in the field of cancer, cancer stem cells (CSCs) have been
proposed as a major factor in tumor initiation, progression, metastasis, and recurrence …