The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …

The cellular complexity and functional diversity of the human immune system necessitate the
use of high-dimensional single-cell tools to uncover its role in multifaceted diseases such as …

Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in
infected tissues, the architecture and composition of which are thought to affect disease …

Immunology researchers are beginning to explore the possibilities of reproducibility, reuse
and secondary analyses of immunology data. Open-access datasets are being applied in …

Mechanism-based strategies to overcome resistance to PD-1 blockade therapy are urgently
needed. We developed genetic acquired resistant models of JAK1, JAK2, and B2M loss-of …

Modern cytometry technologies present opportunities to profile the immune system at a
single-cell resolution with more than 50 protein markers, and have been widely used in both …

The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to
gain mechanistic insight and identify predictive signatures for personalization. However …

Mass cytometry enables the measurement of up to 50 features on single cell. This has
catalyzed a shift toward multidimensional data analysis methods, rather than the manual …

Next-generation tools for multiplexed imaging have driven a new wave of innovation in
understanding how single-cell function and tissue structure are interrelated. In previous …

Flow cytometry (FCM) allows scientists to rapidly quantify up to 50 parameters for millions of
cells per sample. The bottleneck in the application of the technology is data analysis, and …