Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …

Microvesicles or ectosomes represent a major type of extracellular vesicles that are formed
by outward budding of the plasma membrane. Typically, they are bigger than exosomes but …

Blood is donated either as whole blood, with subsequent component processing, or through
the use of apheresis devices that extract one or more components and return the rest of the …

The collection and storage of red blood cells (RBCs) is a logistical necessity to provide
sufficient blood products. However, RBC storage is an unnatural state, resulting in …

Background Characteristics of red blood cells (RBCs) are influenced by donor variability.
This study assessed quality and metabolomic variables of RBC subpopulations of varied …

There is an emerging interest in the risks posed by the ability of blood transfusion to
modulate the immune system of recipients. Observational trials suggest that RBC …

Plasma membrane-derived microvesicles or microparticles (MPs) are sub-cellular vesicles
released upon shear stress, cell activation, injury or apoptosis. They represent factors of the …

Background Leukocytosis is associated with hemorrhage volume and early neurologic
deterioration after intracerebral hemorrhage (ICH). We examined total white blood cell …

The impact of donor characteristics, red cell age, and red cell processing methods on
recipient outcomes is an emerging area of research. Knowledge generated from exploring …

After infection, CMV is latently present in mononuclear cells lifelong. When T lymphocyte
mediated control is lost due to immune suppressive treatment, endogenous CMV replication …