A major manifestation of coronary artery disease is cardiac ischemia/reperfusion injury, with
the extent of injury directly relating to short-and long-term prognosis. Emerging evidence …

Progressive energy deficiency and loss of cardiomyocyte numbers are two prominent factors
that lead to heart failure in experimental models. Signals that mediate cardiomyocyte cell …

Cannabinoids exert various biological effects that are either receptor-mediated or
independent of receptor signaling. Mitochondrial effects of cannabinoids were interpreted …

Diabetic cardiomyopathy is the leading cause of heart failure among diabetic patients, and
mitochondrial dysfunction has been implicated as an underlying cause in the pathogenesis …

Internal and external respiration (mt) Mitochondrial catabolic respiration JkO2 is the O2
consumption in the oxidation of fuel substrates (electron donors) and reduction of O2 …

Over the recent years the view on mitochondria in the heart as a cellular powerhouse
providing ATP supply needed to sustain contractile function, basal metabolic processes, and …

Mitochondrial viscosity affects respiratory state and signal transduction. As a result,
abnormal mitochondrial viscosity leads to diabetes, accelerated aging, insulin resistance …

Cardiovascular complications, such as diabetic cardiomyopathy, account for the majority of
deaths associated with diabetes mellitus. Mitochondria are particularly susceptible to the …

As the knowledge base and importance of mitochondrial physiology to human health
expands, the necessity for harmonizing the terminology concerning mitochondrial …

PIKfyve is an evolutionarily conserved lipid kinase that regulates pleiotropic cellular
functions. Here, we identify PIKfyve as a key regulator of cardiometabolic status and …