Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine

H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Epithelial‑derived head and neck squamous tumourigenesis

CA Shirima, C Bleotu, DA Spandidos… - Oncology …, 2024 - spandidos-publications.com
Head and neck squamous cell carcinomas (HNSCCs), a heterogeneous group of cancers
that arise from the mucosal epithelia cells in the head and neck areas, present great …

Prognostic significance of p16 and its relationship with human papillomavirus status in patients with penile squamous cell carcinoma: results of 5 years follow-up

J Chahoud, NM Zacharias, R Pham, W Qiao, M Guo… - Cancers, 2022 - mdpi.com
Simple Summary Penile Squamous Cell Carcinoma (PSCC) is a rare but aggressive cancer
and approximately 30–50% of cases are associated with high risk human papillomavirus …

Prognostic impact of intra-and peritumoral immune cell subpopulations in head and neck squamous cell carcinomas–comprehensive analysis of the TCGA-HNSC …

M Knebel, S Körner, JP Kühn, S Wemmert… - Frontiers in …, 2023 - frontiersin.org
Background Due to the expanding role of immune checkpoint inhibition in the treatment of
head and neck squamous cell carcinoma, understanding immunological processes in the …

CT‐based deep multi‐label learning prediction model for outcome in patients with oropharyngeal squamous cell carcinoma

B Ma, J Guo, TT Zhai, A van der Schaaf… - Medical …, 2023 - Wiley Online Library
Background Personalized treatment is increasingly required for oropharyngeal squamous
cell carcinoma (OPSCC) patients due to emerging new cancer subtypes and treatment …

IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma

AK Struckmeier, A Radermacher, M Fehrenz… - Journal of Cancer …, 2023 - Springer
Abstract Purpose Strategies for Indolamine-2, 3-dioxygenase 1 (IDO1) inhibition in cancer
immunotherapy once produced encouraging results, but failed in clinical trials. Recent …

Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer

S Körner, T Pick, F Bochen, S Wemmert… - Frontiers in …, 2022 - frontiersin.org
Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a
frequent amplification of chromosomal region 3q26 that encodes, among others, for the …

TREM2 is associated with advanced stages and inferior prognosis in oral squamous cell carcinoma

AK Struckmeier, A Radermacher, M Fehrenz… - Cancers, 2022 - mdpi.com
Simple Summary Triggering receptor expressed on myeloid cells 2 (TREM2) is an appealing
candidate for immunotherapy. However, results regarding its role in multiple cancers are …

[HTML][HTML] Comparison of computed tomography image features extracted by radiomics, self-supervised learning and end-to-end deep learning for outcome prediction of …

B Ma, J Guo, H Chu, LV van Dijk… - Physics and imaging in …, 2023 - Elsevier
Background and purpose To compare the prediction performance of image features of
computed tomography (CT) images extracted by radiomics, self-supervised learning and …

Platelet-to-lymphocyte ratio (PLR) as the prognostic factor for recurrence/residual disease in HSIL patients after LEEP

G Huang, H Gao, Y Chen, W Lin, J Shen… - Journal of …, 2023 - Taylor & Francis
Purpose The platelet-to-lymphocyte ratio (PLR) is considered correlated with cancer
prognosis including cervical cancer, in addition to high-risk papillomavirus (HR-HPV) …