Eryptosis: programmed death of nucleus-free, iron-filled blood cells

P Dreischer, M Duszenko, J Stein, T Wieder - Cells, 2022 - mdpi.com
Human erythrocytes are organelle-free cells packaged with iron-containing hemoglobin,
specializing in the transport of oxygen. With a total number of approximately 25 trillion cells …

Casein kinase 1α mediates eryptosis: a review

A Tkachenko, A Onishchenko - Apoptosis, 2023 - Springer
Eryptosis is a coordinated non-lytic cell death of erythrocytes characterized by cell
shrinkage, cell membrane scrambling, Ca2+ influx, ceramide accumulation, oxidative stress …

Lauric acid, a dietary saturated medium-chain fatty acid, elicits calcium-dependent eryptosis

MA Alfhili, GS Aljuraiban - Cells, 2021 - mdpi.com
Cardiovascular diseases (CVD) are a leading cause of mortality worldwide, and dietary
habits represent a major risk factor for dyslipidemia; a hallmark of CVD. Saturated fatty acids …

Tamoxifen induces eryptosis through calcium accumulation and oxidative stress

MA Alfhili, AM Alyousef, J Alsughayyir - Medical Oncology, 2023 - Springer
Chemotherapy-related anemia is a major obstacle in anticancer therapy. Tamoxifen (TAM) is
an antiestrogen prescribed for breast cancer patients with hemolytic potential and apoptotic …

Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death

MA Alfhili, J Alsughayyir - Xenobiotica, 2023 - Taylor & Francis
Deguelin (DGN), a retinoid isolated from many plants, exhibits a potent anticancer activity
against a wide spectrum of tumour cells. There is a dearth of evidence, however, regarding …

Bufalin reprograms erythrocyte lifespan through p38 MAPK and Rac1 GTPase

MA Alfhili, J Alsughayyir - Toxicon, 2024 - Elsevier
Ample evidence indicates that bufalin (BFN), a cardiotonic steroid in Bufo toad toxin,
possesses a potent anticancer activity mainly by stimulating apoptosis in cancer cells …

Bioymifi, a novel mimetic of TNF-related apoptosis-induced ligand (TRAIL), stimulates eryptosis

MA Alfhili, AM Basudan, FS Aljaser, A Dera… - Medical Oncology, 2021 - Springer
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is a cytokine that initiates
apoptosis upon binding to death receptor 5 (DR5) on cancer cells. Small molecule TRAIL …

Apoptosis-mediated anti-proliferative activity of Calligonum comosum against human breast cancer cells, and molecular docking of its major polyphenolics to …

A Kumar, MA Alfhili, A Bari, H Ennaji… - Frontiers in Cell and …, 2022 - frontiersin.org
Due to poor diagnosis breast cancer in women has emerged as the most common cause of
death disease in developing countries. Medicinal plants have been used for thousands of …

Geraniin inhibits whole blood IFN-γ and IL-6 and promotes IL-1β and IL-8, and stimulates calcium-dependent and sucrose-sensitive erythrocyte death

J Alsughayyir, W Alshaiddi, R Alsubki… - Toxicology and Applied …, 2022 - Elsevier
Correlations between circulating cytokine levels and disease states are well established,
and pharmacological modulation of the immune response is thus an important aspect of the …

Hemocompatibility studies in nanotoxicology: Hemolysis or eryptosis?(A review)

A Tkachenko - Toxicology in Vitro, 2024 - Elsevier
Hemocompatibility evaluation is an important step in nanotoxicological studies. It is
generally accepted that nanomaterials promote lysis of erythrocytes, blood clotting, alter …