[HTML][HTML] A review of food contaminant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and its toxicity associated with metabolic disorders

J Gao, Y Xu, T Zhong, X Yu, L Wang, Y Xiao… - Current Research in …, 2023 - Elsevier
Dioxins are a group of chemicals not only regarded as highly toxic trace environmental
contaminants, but also considered typical contaminants in food. Dioxins spread across the …

Pathophysiological role of BACH transcription factors in digestive system diseases

Q Song, X Mao, M Jing, Y Fu, W Yan - Frontiers in physiology, 2023 - frontiersin.org
BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are
transcription factors that are widely expressed in human tissues. BACH proteins form …

[HTML][HTML] Single-nuclei RNA sequencing assessment of the hepatic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin

R Nault, KA Fader, S Bhattacharya… - Cellular and Molecular …, 2021 - Elsevier
Background and Aims Characterization of cell specific transcriptional responses to
hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice

R Nault, S Saha, S Bhattacharya, S Sinha… - Toxicological …, 2023 - academic.oup.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …

Antioxidative, inflammatory and immune responses in hydrogen peroxide-induced liver injury of tilapia (GIFT, Oreochromis niloticus)

R Jia, J Du, L Cao, Y Li, O Johnson, Z Gu… - Fish & shellfish …, 2019 - Elsevier
Oxidative stress has been implicated in the pathogenesis of many liver diseases in fish, but
the molecular mechanism is still obscure. Here, we used hydrogen peroxide (H 2 O 2) as a …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

KA Fader, R Nault, C Zhang, K Kumagai… - Scientific reports, 2017 - nature.com
Abstract 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor …

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

GN Cholico, K Orlowska, RR Fling, WJ Sink… - Scientific Reports, 2023 - nature.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant that induces the progression of steatosis to steatohepatitis with fibrosis in mice …

Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

R Nault, KA Fader, TA Lydic… - Chemical research in …, 2017 - ACS Publications
The environmental contaminant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) induces
hepatic steatosis mediated by the aryl hydrocarbon receptor. To further characterize TCDD …

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice

KA Fader, R Nault, CM Doskey, RR Fling… - Scientific reports, 2019 - nature.com
Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of
circadian clock regulators, however the impact on clock-controlled metabolism has not been …