Methanotrophy by a Mycobacterium species that dominates a cave microbial ecosystem

RJM Van Spanning, Q Guan, C Melkonian… - Nature …, 2022 - nature.com
So far, only members of the bacterial phyla Proteobacteria and Verrucomicrobia are known
to grow methanotrophically under aerobic conditions. Here we report that this metabolic trait …

Mechanistic insights into sulfur source-driven physiological responses and metabolic reorganization in the fuel-biodesulfurizing Rhodococcus qingshengii IGTS8

J Zumsteg, A Hirschler, C Carapito… - Applied and …, 2023 - Am Soc Microbiol
Comparative proteomics and untargeted metabolomics were combined to study the
physiological and metabolic adaptations of Rhodococcus qingshengii IGTS8 under …

Deciphering the molecular mechanism and regulation of formaldehyde detoxification in Mycobacterium smegmatis

SR Wani, V Jain - Applied and Environmental Microbiology, 2024 - Am Soc Microbiol
The build-up of formaldehyde, a highly reactive molecule is cytotoxic and must be eliminated
for the organism's survival. Formaldehyde detoxification system is found in nearly all …

Mycofactocin is essential for the establishment of methylotrophy in Mycobacterium smegmatis

AA Dubey, V Jain - Biochemical and Biophysical Research …, 2019 - Elsevier
Mycobacterium smegmatis possesses (N, N-dimethyl-4-nitrosoaniline)-dependent (NDMA)
methanol dehydrogenase (Mno) to establish methylotrophy by utilizing methanol as the …

Mycofactocin is associated with ethanol metabolism in mycobacteria

G Krishnamoorthy, P Kaiser, L Lozza, K Hahnke… - MBio, 2019 - Am Soc Microbiol
Mycofactocin (MFT) belongs to the class of ribosomally synthesized and posttranslationally
modified peptides conserved in many Actinobacteria. Mycobacterium tuberculosis …

Decoding phage resistance by mpr and its role in survivability of Mycobacterium smegmatis

SP Seniya, V Jain - Nucleic Acids Research, 2022 - academic.oup.com
Bacteria and bacteriophages co-evolve in a constant arms race, wherein one tries and finds
newer ways to overcome the other. Phage resistance poses a great threat to the …

Oligotrophic Gene Expression in Rhodococcus erythropolis N9T-4 under Various Nutrient Conditions

Y Ikeda, M Kishimoto, M Shintani, N Yoshida - Microorganisms, 2022 - mdpi.com
Rhodococcus erythropolis N9T-4 is a super oligotroph that grows on an inorganic basal
medium without any additional carbon and nitrogen sources and requires CO2 for its …

The catabolism of ethylene glycol by Rhodococcus jostii RHA1 and its dependence on mycofactocin

R Roccor, ME Wolf, J Liu, LD Eltis - Applied and Environmental …, 2024 - Am Soc Microbiol
Ethylene glycol (EG) is a widely used industrial chemical with manifold applications and also
generated in the degradation of plastics such as polyethylene terephthalate. Rhodococcus …

Ms6244 is a novel Mycobacterium smegmatis TetR family transcriptional repressor that regulates cell growth and morphophysiology

SR Wani, AA Dubey, V Jain - FEBS letters, 2023 - Wiley Online Library
Transcriptional factors such as the TetR family of transcriptional regulators (TFTRs) are
widely found amongst bacteria, including mycobacteria, and are accountable for their …

Metabolomics studies to decipher stress responses in Mycobacterium smegmatis point to a putative pathway of methylated amine biosynthesis

A Rizvi, S Yousf, K Balakrishnan, HK Dubey… - Journal of …, 2019 - Am Soc Microbiol
Mycobacterium smegmatis, the saprophytic soil mycobacterium, is routinely used as a
surrogate system to study the human pathogen Mycobacterium tuberculosis. It has also …