Therapeutic potential of melatonin related to its role as an autophagy regulator: A review

JA Boga, B Caballero, Y Potes… - Journal of pineal …, 2019 - Wiley Online Library
There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …

Oncostatic activities of melatonin: Roles in cell cycle, apoptosis, and autophagy

N Targhazeh, RJ Reiter, M Rahimi, D Qujeq, T Yousefi… - Biochimie, 2022 - Elsevier
Melatonin, the major secretory product of the pineal gland, not only regulates circadian
rhythms, mood, and sleep but also has actions in neoplastic processes which are being …

Melatonin attenuates TNF‐α and IL‐1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis

CC Huang, CH Chiou, SC Liu, SL Hu… - Journal of pineal …, 2019 - Wiley Online Library
The hormone melatonin has many properties, including antioxidant, anti‐inflammatory, and
immunomodulatory effects. Melatonin has been demonstrated to be beneficial in several …

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

S Carbajo-Pescador, R Ordoñez, M Benet… - British journal of …, 2013 - nature.com
Background: Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular
endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to …

Basic mechanisms involved in the anti-cancer effects of melatonin

MD Mediavilla, EJ Sanchez-Barcelo… - Current medicinal …, 2010 - ingentaconnect.com
It is commonly accepted that melatonin (N-acetyl-5-methoxytryptamine), the most relevant
pineal secretory product, has oncostatic properties in a wide variety of tumors and …

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

M Bizzarri, S Proietti, A Cucina… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Compelling evidence has highlighted the complex pleiotropic functions elicited
by the melatonin in cancer cells. Melatonin behaves as a 'smart killer', ie, modulating anti …

An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and …

S Mehrzadi, MH Pourhanifeh, A Mirzaei… - Cancer cell …, 2021 - Springer
Cancers are serious life-threatening diseases which annually are responsible for millions of
deaths across the world. Despite many developments in therapeutic approaches for affected …

Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats

E Guneli, K Tugyan, H Ozturk, M Gumustekin… - European Surgical …, 2008 - karger.com
Background: It is well known that diabetes mellitus is associated with impairment of testicular
function. In the present study, we aimed to demonstrate the effect of melatonin on testicular …

[PDF][PDF] Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line.

J Martin-Renedo, JL Mauriz, F Jorquera… - Journal of pineal …, 2008 - academia.edu
Melatonin reduces proliferation in many different cancer cell lines. However, studies on the
oncostatic effects of melatonin in the treatment of hepatocarcinoma are limited. In this study …

Melatonin as an antioxidant and its semi-lunar rhythm in green macroalga Ulva sp.

O Tal, A Haim, O Harel… - Journal of experimental …, 2011 - academic.oup.com
The presence and role of melatonin in plants are still under debate owing to difficulties of
identification and quantification. Accordingly, although it has been frequently proposed that …