SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients
Hyper-induction of pro-inflammatory cytokines, also known as a cytokine storm or cytokine
release syndrome (CRS), is one of the key aspects of the currently ongoing SARS-CoV-2 …
release syndrome (CRS), is one of the key aspects of the currently ongoing SARS-CoV-2 …
[HTML][HTML] NanoSIMS for biological applications: current practices and analyses
Secondary ion mass spectrometry (SIMS) has become an increasingly utilized tool in
biologically relevant studies. Of these, high lateral resolution methodologies using the …
biologically relevant studies. Of these, high lateral resolution methodologies using the …
AutoDock Vina 1.2. 0: New docking methods, expanded force field, and python bindings
J Eberhardt, D Santos-Martins… - Journal of chemical …, 2021 - ACS Publications
AutoDock Vina is arguably one of the fastest and most widely used open-source programs
for molecular docking. However, compared to other programs in the AutoDock Suite, it lacks …
for molecular docking. However, compared to other programs in the AutoDock Suite, it lacks …
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
OS Blomberg, L Spagnuolo, H Garner, L Voorwerk… - Cancer Cell, 2023 - cell.com
Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research
into the mechanisms underlying response to ICB has predominantly focused on T cells; …
into the mechanisms underlying response to ICB has predominantly focused on T cells; …
Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2
The COVID-19 pandemic has highlighted that new diagnostic technologies are essential for
controlling disease transmission. Here, we develop SHINE (Streamlined Highlighting of …
controlling disease transmission. Here, we develop SHINE (Streamlined Highlighting of …
A gravitational-wave measurement of the Hubble constant following the second observing run of advanced LIGO and Virgo
BP Abbott, R Abbott, TD Abbott… - The Astrophysical …, 2021 - iopscience.iop.org
Gravitational waves (GWs) from compact binary coalescences allow for the direct
measurement of the luminosity distance to their source. This makes them standard-distance …
measurement of the luminosity distance to their source. This makes them standard-distance …
SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues
Fluorescence in situ hybridization (FISH) reveals the abundance and positioning of nucleic
acid sequences in fixed samples. Despite recent advances in multiplexed amplification of …
acid sequences in fixed samples. Despite recent advances in multiplexed amplification of …
The citation advantage of linking publications to research data
Efforts to make research results open and reproducible are increasingly reflected by journal
policies encouraging or mandating authors to provide data availability statements. As a …
policies encouraging or mandating authors to provide data availability statements. As a …
Massively parallel de novo protein design for targeted therapeutics
De novo protein design holds promise for creating small stable proteins with shapes
customized to bind therapeutic targets. We describe a massively parallel approach for …
customized to bind therapeutic targets. We describe a massively parallel approach for …
Deep convolutional models improve predictions of macaque V1 responses to natural images
Despite great efforts over several decades, our best models of primary visual cortex (V1) still
predict spiking activity quite poorly when probed with natural stimuli, highlighting our limited …
predict spiking activity quite poorly when probed with natural stimuli, highlighting our limited …